|Modified | DDT |>| MON.MAR,990301,11:30-4 |||CoSy/Home ; CoSy/Current||© Coherent Systems Inc .|
============================: THU.FEB,990225 :============================ JackLuchese ( ex - J&J Roror ) : Biopharm . CytRx Corp : w/i 2 yr of mkting product . ( w Mark Reynolds ) in faze 3 pivitol trial . High value Human theraputics . FLOCOR sickle cell disease . 100M$ % yr US mkt potential | .9 margin . Long Strong Patents . ( < 2015 ) 15M$ Cash | vs value . Chmn : Max Link PhD : Corange Sandos Ciba-Geigy FLOCOR(tm) Poloxamer 188 surficant . for acute vascular occlusive episodes : IV administration . Improves bloodflow . like waxing car . anywhere blood is not flowing . African , Mediteranian . 48 hr apply on crisis : need for pain reduction down 4.3x Pain intensity -.4 Primary endpoint : reduce Crisis Duration - days of hospitalization . Reached mid point of Faez3 study . > 112 patients in 45 cities Contract to produce w Abbott which is also handling FDA etc paper work . Blood cells must be deformable . Sickle cells deformed , rigid , sticky . Cause : spleen obstruction in 2yr old babys . Progressive decrease in renal & Pulmonary fn . Joint pain . - leg ulcers . | 25 yr less life span . Obstruction of flow by sickled red blood cells . Severe Pain Progressive end organ dysfunction . crises Obvious wider applicability , but get Orphan Drug Status :Tax perks , but main advanatage : regulatory fast trak . $100-300M Hi margin ww mkt . Only need ~ 15 Acnt Reps got $400k grant from FDA for Faez 3 . No current alternative treatment . 15000 75000 severe & other episode % yr . Patients see Hematologist specialists . - 1 or 2 reps in 5 bouroughs Genetics from central & western Africa to central & So America mainly . ( single gene provides Malaria prevention . ) Insurance & State & Fed pay . Have established safety - efficacy . Acute lung embolism trial starting in 60 days . Other Teks : 6 other programs from Research to Faez 2 . 1.90 book | 1.25 - 2. $ price range . |17:20| ?s : antibiotics Newborn testing increased life span . | Abe : outpatient ? Can be done . normally Hospital based Hemotologists | Montefiore Dr ? she hi on her experience . | undervalued because more $ moving into hi Caps . | Not blood thinner like cumidin . | Early res in stroke where blood not flowing . | substitute for angioplasty ? no that large vessel obstruction problem . | Faez 3 done by EoY . | 3pl line of patent defense : Orphan , Children , use patents . | Diabetic vascular problems ? excellent comment . IV chronic | surfactant - ~ interfere w hemiglobin resparation . | Done bunch of devestiture for 20M$ . | < .5B$ % yr , not worth Major`s time . | Clare : deals in work ? always talking . no comments . | Jerry : 1 trick pony ? looking @ acqing complementary prods . |17:38| Cause of crisis ? multiple factors , change in hemiglobin content , moisture IV injection of several cc`s of "soap" solution . veins don`t mind . Valuation ?