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============================: THU.OCT,991028 :============================ 19:30| NYAS Orthopedic Engineering . Karen Warden . 2 E 63 . Case Western : 10 yrs in Acadamia , consultant , FDA . `99 Volvo Low BackPain |19:41| 1862 : Edwin Smith Egypt Papyrus . spinal & long bone fractures . Statics : Free Body Force Diagram equilibrium . Kinematics : Maure - Muybridge . gait analysis . Beautiful Baseball pitch trajectory . Dynamics . Kinetics - forces , torques , presures , & work . Calf spine motions vs loads . then created defect . Strengths of materials : Bone : Collagen Hydroxyapatite matrix . Spongy bone . Viscoelastic - strength depends on time scale - speed . Functional adaptation : Wolff 1894 : Fnctional Adaptation - self optimizing structure . Stress around implant . mediation of adaptation not understood Finite Element analysis . Connective Tissue - articular cartilage - porous fluid-filled exudiedin front of pressure peak . pumps neutrients too . Tendons ( meat to meat or bone ) - ligaments - bone to bone . collegen & elastic fibres . Muscles - myacin climbing along actin . Non Bio- materials . Lister - aseptic tek in 1860s . steel in 1900s - 30s cobalt crom moly stanless steel ., `40s first use of titanium WWII PMMA acrylics - low rejection . Hi molecular weight polyethelene . PAEKeytones composite base Ceramics coated for biocompatability . Biocompatability : Material response - swelling leaching , corrosion , friction . Host Response : inflamation & foreign body reaction . specific allergys - eg , nickle ; toxicity & mutogenicity ; Adaptation . seeks optimal mechanical load - resorbed away from stiff metal Device related osteoporosis in bone Jules Pen 1893 : sholder , platnum joint replacement surgury . can replace almost any joint now day , finger , hip , knee 600k % yr . Fracture Fixation devices - promote bony fusion . @ curve of spine . carbon polymer imagining xparent - can see bone heal . Need to speak w : Marketing - white papers . Surgeon argot - bent screw to turn angle . Researchers - esoteric - testing methods . Tek writers FDA : Slide image : possum run over by mid road yellow stripes . Rules & regs - perfect people in unbelievable system . Try to create 'comfort level ' . Stage 3 clinical - 5-7 yr . Patent Attnys : have own precise language . need to know current tek & your difference - lab notebook . Failure : patient non-compliance . materials , surgeon . Litigation Attnys : don`t speak at all . Scoliosis - Future : materials ; osteogenic growth factors . bioresorbable Ceramics . Hydro gels for disk replacements . | Slide : Portugese Chapel built of bones for halowen |20:43| Qs ? Ligaments - sprains ? not my specialty . Knee carbon fibre braids . problem : splintered . Transplantation . | Sacrum replacement ? custom | | chin on chest osteoporotic wedge collapse of vertebrae | Silicone rubber ? finger joint failed faster . In spine , interfaced w titanium , didn`t grip & poor lateral strength . | Airport detectors IDs : generally not set off . | desperate need of new materials . composite w closer modulus to natural . better tripological properties . | Cements ? some , roughen surface . Finite element Analysis ? Titaniums too stiff . | magnets ? no really solid evidence of value . memory metals | deep wound infection problem in old wounds . |21:4| new joints - closer to $25k than $100k . This is what interests me ; see http://cosy.com/trnsprt/seizure.htm >
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