Subject: Re: [drugwar] The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
Date: Sat, 4 Oct 2003 16:37:50 -0400
To:        <drugwar@mindvox.com>
From:     Bob Armstrong <bob@cosy.com>

 Interesting on several levels .

 For one thing , it along with many other threads of info ,
 shows how crazy the notion that everyone's brain chemistry 
 is the same , and thus how crazy any universal prohibitions
 are .

On Thu, 02 Oct 2003 19:31:04 -0400, Tim Meehan wrote:
>=A0http://jpet.aspetjournals.org/cgi/content/abstract/307/1/129
>=A0The Journal of Pharmacology And Experimental Therapeutics
>=A0NEUROPHARMACOLOGY
>=A0The Endogenous Cannabinoid System Regulates Seizure Frequency=
 and Duration in a
>=A0Model of Temporal Lobe Epilepsy
>
>=A0Furthermore, we determined that during an short-term=
 pilocarpine-induced
>=A0seizure, levels of the endogenous CB1 ligand=
 2-arachidonylglycerol increased
>=A0significantly within the hippocampal brain region. These data=
 indicate not only
>=A0anticonvulsant activity of exogenously applied cannabinoids but=
 also suggest
>=A0that endogenous cannabinoid tone modulates seizure termination=
 and duration
>=A0through activation of the CB1 receptor. 
 
 I find the effects on the hippocampus particularly interesting=
 .
 While I've been away from it for getting on 25 years , I spent=
 the
 `70s trying to figure out how brains work . I was approaching it=
 
 from the psychophysical , mathematical , information flow side=
 .
 The psychochem guys were upstairs ( boy they had good stuff ) .=
 
 So all the chem and physio was not my core interest . But I=
 learned
 enough of the anatomy , etc , to put together with the math to 
 come to the hypothesis that , to quote from
  http://cosy.com/views/psykofiz.htm , ( 1992 )

   I concluded [ consciousness ] may arise from a folding in=
 time
   of the brain`s patterns of activity back upon themselves=
 creating
   a singularity in time and space - an interval of mutual=
 awareness .
   The Hippocampus appears to have the appropriate structure for
   spreading its information flows out in time , and to be=
 clinically
   related to the phenomenon of consciousness 
 
 The connection with cannabinoid receptors in terms of the=
 distortions
 of time and space metrics experienced , is thus very=
 interesting
 ( to me ( James Watson's caveat ) ) .

--=A0
=A0Bob Armstrong -- http://CoSy.com -- 212-285-1864
Return our Right to Relax :
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=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A02003/10/04 4:09:10 PM